Juyoung Shim

Juyoung Shim
Title Assistant Professor of Biology
Telephone 207-621-3027
Address

Jewett Hall, Room 108
UMA Augusta Campus
Bio

Dr. Juyoung Katherine Shim joined the UMA biology department after working as a post-doctoral research fellow, studying at how dietary restriction changes gene regulation and lifespan using C. elegans at the MDI Biological Laboratory. She received her PhD in Biochemistry and Molecular Biology from University of Maine in the laboratory of Dr. Julie Gosse, focused on investigating molecular mechanisms underlying effects of environmental toxicants, such as arsenic and synthetic antimicrobial agent Triclosan, on mast cell and mitochondrial function. Since she and her husband landed in Presque Isle, Maine as international students from Seoul Korea in 1994, they have enjoyed Maine’s outdoor activities and friendly communities. She is very excited to be at the UMA where she teaches basic and advanced A&P, Biochemistry, and pathophysiology. She also hopes to expand her understanding of aging biology and toxicology, to build on the research aimed at understanding how adaptive responses and associated gene regulation maintain healthy tissue function. In her spare time, she enjoys yoga, hiking and traveling and she is a licensed hand-acupuncturist from Korea.

Education

University of Maine (2013-2018) PhD. In Biochemistry concentration in Toxicology.
Bates College (2001-2005): BS in Biochemistry.
Hankook University of Foreign Studies (Seoul, Korea): BA in English/ Minor in Education.

Peer-Reviewed Scientific Publications

  1. Juyoung Shim, Lisa Weatherly, Molly Caron, Logan Gerchman, Andrew Hart, Julie Gosse. “Antimicrobial agent triclosan suppresses mast cell signaling via phospholipase D inhibition.” J Appl Toxicol. 2019. doi:10.1002/jat.3884
  2. Juyoung Shim, Rachel Kennedy, Lisa Weatherly, Andrew V. Abovian, Hina N Hashmi, Atefeh Rajaei, Julie Gosse. “Searching for Tryptase in the RBL-2H3 mast cell model: Preparation for comparative mast cell toxicology studies with zebrafish.” J Appl Toxicol. 2019. Vol. 39 (3): 473-484 doi:10.1002/jat.3738
  3. Juyoung Shim, Rachel Kennedy, Lisa Weatherly, Lee Hutchinson, Jonathan Pelletier, Hina Hashmi, Kayla Blais, Alejandro Velez, Julie Gosse. “Arsenic inhibits mast cell degranulation via suppression of early tyrosine phosphorylation events.” J Appl Toxicol. 2016. Vol. 36, No. 11, pp 1146-1159. doi:10.1002/jat.3300
  4. Juyoung Shim, Lisa Weatherly, Richard Luc, Maxwell Dorman, Andrew Neilson, Ryan Ng, Carol Kim, Paul Millard, Julie Gosse. “Triclosan is a mitochondrial uncoupler in live zebrafish.” J Appl Toxicol. 2016. Vol. 36, No. 12, pp 1662-1667. doi:10.1002/jat.3311
  5. Lisa Weatherly, Andrew Nelson, Juyoung Shim, Abigail Riitano, Roger Sher, Samuel Hess, Julie Gosse. “Antimicrobial agent triclosan disrupts mitochondrial structure, revealed by super-resolution microscopy, and inhibits mast cell signaling via calcium modulation.” Toxicol Appl Pharmacol. 2018. Vol. 349, pp 39-54. doi: 10.1016/j.taap.2018.04.005
  6. Katrina Daigle, Ella Sulinski, Juyoung Shim, Nicole Heller, Julie Gosse, Marie Hayes “Impaired Maternal Responsivity and Oxytocin Suppression in Opioid Dependent Mothers.” Submitted to Developmental psychobiology. 2019. doi: 10.1002/dev.21897
  7. Sarah Conlin, M. Scarlett Tudor, Juyoung Shim, Andrew Neilson, Julie Gosse, Heather Hamlin. “Elevated nitrate alters the metabolic activity of embryonic zebrafish.” Environmental Pollution, 2017. Vol 235, pp 180-185. doi.org/10.1016/j.envpol.2017.12.069
  8. Lisa Weatherly, Juyoung Shim, Hina Hashmi, Rachel Kennedy, Samuel Hess, Julie Gosse. “Antimicrobial agent triclosan is a proton ionophore uncoupler of mitochondria in living rat and human mast cells and in primary human keratinocytes.” J Appl Toxicol. 2016. Vol. 36, pp. 777–789. doi:10.1002/jat.3209
  9. Lisa Weatherly, Rachel Kennedy, Juyoung Shim, Julie Gosse. “A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent.” J. Vis. Exp. 2013. Vol. 81: 50671. doi:10.3791/50671
  10. Kristin Gabor, Jeremy Charette, Matthew Pietraszewski, Dylan Wingfield, Juyoung Shim, Paul Millard, Carol Kim. “A DN-mda5 Transgenic Zebrafish Model Demonstrates that Mda5 is Essential to Snakehead Rhabdovirus Resistance.” Dev and Comp Immunol. 2014. Vol. 51, No.12, pp298-304. doi: 10.1016/j.dci.2015.01.006
  11. Amanda N. Kortum, Ivan Rodriguez-Nunez, Jibing Yang, Juyoung Shim, Donna Runft, Marci L. O’Driscoll, Robert N. Haire, John P. Cannon, Poem M. Turner, Ronda T. Litman, Carol H. Kim, Melody N. Neely, Gary W. Litman, Jeffrey A. Yoder. “Differential expression and ligand binding indicate alternative functions for zebrafish polymeric immunoglobulin receptor (pIgR) and a family of pIgR-like (PIGRL) proteins.” Immunogenetics. 2014. Vol. 66, No. 4, pp267-79 doi: 10.1007/s00251-014-0759-4
  12. Kristin Gabor, Chad R. Stevens, Matthew J. Pietraszewski, Travis J. Gould, Juyoung Shim, Jeffrey A.Yoder, Siew Hong Lam, Zhiyuan Gong, Samuel T. Hess, Carol Kim. “Super-resolution microscopy reveals that caveolin-1 is required for antiviral immune response.” PLoS One. 2013. Vol.9, No.7. doi: 10.1371/journal.pone.0068759